5-HTP ( 5-Hydroxytryptophan ) - Pure Compound - Powder

5-Hydroxytryptophan

Other Names: 5-HTP, 5-Hydroxy-L-tryptophan

CAS Number: 56-69-9
Sum Formula: C11H12N2O3
Molar Mass: 220.23 g/mol
Appearance: White to off-white crystalline powder

5-Hydroxytryptophan (5-HTP) is a hydroxylated derivative of L-tryptophan and an aromatic amino acid containing an indole ring substituted with a hydroxyl group. Its chemical structure is closely related to L-tryptophan, with hydroxylation occurring at the 5-position of the indole system. In biological systems, 5-HTP can be formed through enzymatic hydroxylation of L-tryptophan, a reaction catalyzed by tryptophan hydroxylases or engineered aromatic amino acid hydroxylases. This transformation has been extensively investigated in biochemical and metabolic-engineering studies aimed at developing microbial production systems for hydroxylated tryptophan derivatives. The distinctive spectroscopic properties of the 5-hydroxyindole group have also made 5-HTP useful in studies of proteins and molecular interactions. Researchers have incorporated 5-HTP into proteins as a noncanonical amino acid, enabling spectroscopic analysis and selective chemical modification of protein structures.

Applications
Pharmaceutical Industry: Used in the synthesis of serotonin-related pharmaceuticals.

5-Hydroxytryptophan is used in biochemical and molecular research as an intrinsic spectroscopic probe. Its characteristic absorption and fluorescence properties have been exploited to investigate protein structure, protein–DNA interactions and molecular association processes.

It has also been incorporated into proteins as a noncanonical amino acid in engineered bacterial systems. Studies have demonstrated genetically controlled incorporation of 5-HTP into proteins and subsequent site-selective modification of the incorporated residue with aromatic diazonium compounds.

5-HTP has additionally been investigated in surface-chemistry and materials research, including studies of its adsorption on silver nanoparticles and its incorporation into epoxy-based systems evaluated for corrosion-related properties.

Safety
Signal Word: Warning

Hazard Statements:
H302+H332: Harmful if swallowed or inhaled.

Precautionary Statements:
P101: If medical advice is needed, have the product container or label on hand.
P102: Keep out of reach of children.
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P312: If feeling unwell, contact a POISON CENTER.
P501: Dispose of contents/container to an authorized waste disposal facility or return to supplier.

First Aid Measures
Eye Contact: Rinse thoroughly with water. Seek medical attention if irritation persists.
Skin Contact: Wash with soap and water. Seek medical attention if irritation occurs.
Inhalation: Move to fresh air. If breathing is difficult, seek immediate medical attention.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical advice immediately.

Handling and Storage
Storage Conditions: Store in a cool, dry, and well-ventilated area. Keep containers tightly closed.
Handling Precautions: Avoid inhaling dust or vapors. Use appropriate personal protective equipment (PPE).