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Alkyl nitrites are volatile organic esters of nitrous acid with the general formula R–ONO. They rapidly release nitric oxide, causing short-lived vasodilation and smooth-muscle relaxation. When misused as “poppers” by inhalation, they can trigger acute hypotension, dizziness, headaches, fainting, dangerous interactions with PDE-5 inhibitors (e.g., sildenafil), and in rare cases methemoglobinemia, so exposure carries real cardiovascular risk.
Isoamyl nitrite ( Isopentyl nitrite ) [ CAS: 110-46-3 ] - 1000ml 1L
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Isoamyl nitrite ( Isopentyl nitrite ) [ CAS: 110-46-3 ] - 10ml
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Isoamyl nitrite ( Isopentyl nitrite ) [ CAS: 110-46-3 ] - 30ml
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Isopropyl Nitrite
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n- Amyl Nitrite ; Nitramyl ( Pentyl Nitrite ) | Pure
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N-Hexyl Nitrite
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Alkyl nitrites are O-nitroso esters formed from alcohols and nitrous acid, typically prepared via nitrosation of alcohols with nitrite salts under acidic conditions. The O–N bond is relatively weak and prone to homolysis or heterolysis, enabling rapid generation of nitric oxide (NO) or nitrosyl species in vivo. The pharmacodynamic effect is mediated by NO activation of soluble guanylate cyclase, elevating cGMP levels and promoting vascular smooth-muscle relaxation; this explains their fast onset and brief duration.
Chemically, alkyl nitrites participate in reactions characteristic of nitrosating agents and can serve as NO donors or intermediates in diazotization/nitrosation pathways. They are generally low-boiling, lipophilic liquids, often light-sensitive, and can decompose to NO, NO₂, and corresponding alcohols/aldehydes depending on conditions. The alkyl group influences stability and volatility: smaller, more branched nitrites tend to be more volatile and faster-acting as NO sources.
From a toxicological standpoint, their strong vasodilatory action can cause abrupt drops in blood pressure and reflex tachycardia. Oxidation of hemoglobin to methemoglobin (Fe³⁺) is a recognized hazard at higher exposures, reducing oxygen-carrying capacity and potentially leading to cyanosis and hypoxia. Risk increases with repeated dosing, pre-existing cardiovascular disease, anemia, or concurrent vasodilators. Common examples include amyl, butyl, and isobutyl nitrite, with historical medical use of amyl nitrite for acute angina largely replaced by safer, longer-acting nitrates.