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Nicotinamide Riboside
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Description
Nicotinamide Riboside
Other Names: 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridin-1-ium, NR⁺, Nicotinamide β-D-ribonucleotide (reduced form), Pyridinium-1-β-D-ribofuranoside-3-carboxamide
CAS Number: 1341-23-7
Sum Formula: C₁₁H₁₆N₂O₅⁺ (as the pyridinium cation)
Molar Mass: 255.26 g/mol
Appearance: White to off-white crystalline powder
Nicotinamide riboside (NR⁺) is a pyridinium-nucleoside form of vitamin B3 composed of nicotinamide and ribose. It is an NAD⁺ precursor and is structurally similar to nucleotides, making it relevant in nucleotide chemistry, coenzyme biosynthesis, and bioengineering applications involving redox-active cofactors.
Chemical and Physical Properties
Density: ~1.4 g/cm³ (estimated)
Melting Point: ~120–125°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Freely soluble
Solubility in Other Solvents: Slightly soluble in methanol; insoluble in nonpolar solvents
Odor: Odorless
Applications
Nucleoside Chemistry: Used in the synthesis of NAD⁺ analogues and as a building block for nucleotide derivatives.
Biochemical Research: Investigated for its role in NAD⁺ biosynthesis and energy metabolism studies.
Organic Synthesis: Precursor for functionalized ribosides and pyridinium-based redox agents.
Surface Chemistry: Applied in biosensor development and immobilization of cofactors on electrodes.
Polymer and Material Science: Explored for use in NAD⁺-mimicking polymers and responsive hydrogels.
Safety
This chemical does not meet GHS hazard criteria for 100% (2 of 2) of all reports.
Handling and Storage
Storage Conditions: Store in a tightly sealed, light-protected container in a cool, dry environment. Avoid exposure to heat, moisture, and strong oxidizing agents.
Handling Precautions: Handle in a low-humidity environment to preserve stability. Use appropriate PPE and avoid dust formation.