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JXL-082 ( JXL082 )
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Description
Ethyl (E)-3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-cyanoprop-2-enoate
Pure compound
JXL082 is an experimental small-molecule mitochondrial pyruvate carrier (MPC) inhibitor investigated in preclinical research as a potential topical hair-growth agent. In published laboratory studies, compounds from this series were designed to alter mitochondrial pyruvate metabolism in hair-follicle stem cells, with the goal of promoting activation of dormant follicles and supporting hair regeneration pathways. Current evidence is limited to research and early preclinical development, and JXL082 is not an approved medicine for human use.
Chemical and Physical Properties of Pure compound
- Chemical name / IUPAC name: ethyl (E)-3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-cyanoprop-2-enoate
- Synonym: JXL-082
- CAS number: 2260696-75-9
- PubChem CID: 137384919
- ChEMBL ID: CHEMBL4746172
- Molecular formula: C22H15F6N3O2
- Molecular weight / molar mass: 467.37 g/mol (calculated from the published molecular formula C22H15F6N3O2)
- SMILES:
CCOC(=O)/C(=C/C1=CN(C2=C1C=CC=N2)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)/C#N - InChI:
InChI=1S/C22H15F6N3O2/c1-2-33-20(32)14(10-29)8-15-12-31(19-18(15)4-3-5-30-19)11-13-6-16(21(23,24)25)9-17(7-13)22(26,27)28/h3-9,12H,2,11H2,1H3/b14-8+ - InChIKey: AIPLDVOUZVHAOG-RIYZIHGNSA-N
Applications
⚠️ This raw material is intended solely for laboratory and scientific research on receptor signaling / mitochondrial metabolism / hair-follicle biology / analytical method development. It is supplied exclusively for in vitro, analytical, or other non-clinical research purposes. Not for human or veterinary use. Not for use in diagnosis, treatment, cure, or prevention of any disease. To be handled only by qualified professionals in appropriate research settings
Handling and Storage
Handling: Avoid contact with skin, eyes, and clothing. Prevent inhalation of dust. Use only with adequate ventilation.
Storage: Store tightly sealed, in a cool, dry environment. Protect from moisture and incompatible reagents (especially bases and strong oxidizers).