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Isopropyl Bromide
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Description
Isopropyl Bromide
Other Names: 2-Bromopropane, 2-Propyl bromide, sec-Propyl bromide
CAS Number: 75-26-3
Sum Formula: C₃H₇Br
Molar Mass: 122.99 g/mol
Appearance: Colorless to pale yellow liquid
Isopropyl bromide is a secondary alkyl halide used in organic synthesis as an alkylating agent. It is reactive toward nucleophilic substitution and elimination reactions, making it valuable in laboratory and industrial chemistry for introducing isopropyl groups into target molecules.
Chemical and Physical Properties
Density: 1.31 g/cm³
Melting Point: –89°C
Boiling Point: 59–60°C
Solubility in Water: Slightly soluble
Solubility in Other Solvents: Miscible with organic solvents such as ethanol, ether, and chloroform
Odor: Sweet, ether-like odor
Applications
Organic Synthesis: Used as an intermediate in alkylation reactions (SN1/SN2 mechanisms).
Pharmaceuticals and Agrochemicals: Employed in the production of isopropylated compounds.
Research: Utilized in reaction mechanism studies and synthesis of substituted hydrocarbons.
Chemical Manufacturing: Precursor for other brominated and isopropyl-containing chemicals.
Safety
Signal Word: Warning
H225 (98.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]
H360 (95.3%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H373 (97.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P203, P210, P233, P240, P241, P242, P243, P260, P280, P303+P361+P353, P318, P319, P370+P378, P403+P235, P405, and P501
Handling and Storage
Storage Conditions: Store in tightly sealed containers in a cool, dry, well-ventilated place away from heat, ignition sources, and incompatible materials such as strong bases and oxidizers.
Handling Precautions: Use only in fume hoods or with adequate ventilation. Avoid inhalation and direct contact. Employ full personal protective equipment when handling.