4-Fluoro-P2NP | 4F-P2NP | 1-(4-Fluorophenyl)-2-nitropropene )

1-(4-Fluorophenyl)-2-nitropropene
Other Names:

• 1-(4-Fluorophenyl)-2-nitroprop-1-ene

• (E)-1-(4-Fluorophenyl)-2-nitropropene

• 4-Fluorophenyl-2-nitropropene

CAS Number: 775-31-5
Sum Formula: C₉H₈FNO₂
Molar Mass: 181.16 g/mol
Appearance: Yellow to orange crystalline solid

1-(4-Fluorophenyl)-2-nitropropene is an aromatic nitroalkene featuring a para-substituted fluorine atom on the phenyl ring. It is widely used in organic synthesis and research as an intermediate in the production of substituted phenethylamines and in nitroalkene-related transformations.

Chemical and Physical Properties
Density: 1.230 ± 0.06 g/cm³ (predicted)
Melting Point: 64–66°C
Boiling Point: 262.2 ± 15.0°C (predicted)
Solubility in Water: Practically insoluble
Solubility in Other Solvents: Soluble in ethanol, acetone, chloroform, and other polar organic solvents
Odor: Mild aromatic odor

Applications
Organic Synthesis: Used as a key intermediate in the preparation of fluorinated aromatic derivatives.
Chemical Research: Employed in reactivity studies involving conjugated nitroalkenes, particularly Michael addition and condensation reactions.
Fluorinated Compound Development: Used in structure–activity relationship (SAR) research for materials or active molecule discovery.

Safety

Signal Word: Warning

Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, well-ventilated area. Protect from light, heat, and incompatible materials such as oxidizers.
Handling Precautions: Avoid dust formation and direct contact with skin or eyes. Use appropriate PPE and handle under a fume hood when possible.