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P - Toluenesulfonic acid P-Tos Tosylic Acid - 5000g
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Description
P-Toluenesulfonic Acid (PTSA)
Other Names:
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P-Toluenesulphonic acid
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Tosylic acid
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4-Methylbenzenesulfonic acid
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PTSA
Chemical Formula: C₇H₈O₃S
Molar Mass: 172.20 g/mol
CAS Number: 104-15-4
Appearance: White to off-white crystalline solid or granules
Odor: Slightly pungent, characteristic
P-Toluenesulfonic acid is a strong organic acid derived from toluene and widely used in organic synthesis as a non-oxidizing acid catalyst. It is soluble in water and polar organic solvents and often used in its monohydrate form.
Chemical and Physical Properties
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Density: ~1.24 g/cm³
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Melting Point: 103–106 °C (anhydrous)
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Solubility: Soluble in water, alcohols, acetone, and other polar solvents
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Acidity (pKa): ~−2.8 (strong organic acid)
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Form: Often available as the monohydrate (C₇H₈O₃S·H₂O)
Applications
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Catalysis: Used as an acid catalyst in esterification, alkylation, acetal formation, and elimination reactions.
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Polymer Chemistry: Initiator or catalyst for polymerization reactions.
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Organic Synthesis: Employed in protecting group strategies and sulfonation reactions.
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Drying Agents: In specific reactions, acts as a reagent to remove water or drive equilibrium.
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Resin and Coating Industry: Included in curing formulations for epoxy and phenolic resins.
Safety
Signal Word: ⚠️ Danger
H314 (42.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (62.1%): Causes skin irritation [Warning Skin corrosion/irritation]
H318 (37%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (62.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (87%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501
Handling and Storage
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Handling: Avoid contact with skin and eyes. Do not inhale dust. Handle with appropriate PPE.
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Storage: Store in a tightly sealed container in a dry, well-ventilated area. Protect from moisture and incompatible materials (e.g., strong bases, oxidizers).
Environmental Considerations
Not classified as environmentally hazardous in small laboratory quantities, but larger spills should be prevented from entering waterways. Dispose of according to local environmental regulations.