N-Methylformamide (NMF) N-Methylformamide >99% | P.a. purity

N-Methylformamide (NMF)
Other Names: N-Methylmethanamide
Chemical Formula: C₂H₅NO
Molar Mass: 59.07 g/mol
CAS Number: 123-39-7
Purity: >99%
Appearance: Colorless to pale yellow liquid
Odor: Slight, amine-like odor

N-Methylformamide is a polar aprotic solvent and organic intermediate from the formamide family. It is used in synthetic chemistry for acylation, condensation, and cyclization reactions, as well as a reaction medium in high-polarity environments.

Chemical and Physical Properties

• Density: 1.007 g/cm³ at 20 °C

• Boiling Point: 199–201 °C

• Melting Point: −3.5 °C

• Flash Point: 109 °C (closed cup)

• Solubility: Miscible with water, alcohols, ethers, acetone, and chloroform

• Refractive Index: 1.433 at 20 °C

• Viscosity: ~2.4 mPa·s at 25 °C

• Polarity: High dipole moment, suitable for solvation of ionic or highly polar compounds

Applications

Solvent for Organic Synthesis

• Used in condensation reactions, nucleophilic substitutions, and as a reaction medium for polymer and pharmaceutical intermediates.

High-Polarity Solvent Systems

• Functions as a solvent in spectroscopy, high-performance liquid chromatography (HPLC), and polar reaction systems.

Chemical Intermediate

• Precursor for N-methylated derivatives, heterocycles, and fine chemicals.

Research and Development

• Employed in structural elucidation studies involving solvation and hydrogen bonding mechanisms.

Safety

Signal Word: Warning

Hazard Statements:

• H302: Harmful if swallowed

• H312: Harmful in contact with skin

• H332: Harmful if inhaled

• H360D: May damage the unborn child

Precautionary Statements:

• P201: Obtain special instructions before use

• P280: Wear protective gloves, clothing, and eye/face protection

• P261: Avoid breathing mist/vapors

• P303+P361+P353: IF ON SKIN (or hair): Remove contaminated clothing. Rinse skin with water

• P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing

• P501: Dispose of contents/container in accordance with local regulations

Handling and Storage

• Handling: Use only in well-ventilated areas or under fume hoods. Avoid contact with skin, eyes, and clothing.

• Storage: Store tightly closed in a dry, cool, and well-ventilated area. Protect from heat and incompatible substances.

• Incompatibilities: Strong oxidizers, acids, and alkali metals

Environmental Considerations

Avoid uncontrolled release into the environment. Follow appropriate procedures for chemical disposal.