L-Norvaline
Other Names: 2-Aminopentanoic acid, 2-Aminovaleric acid, α-Aminopentanoic acid, Propylglycine

CAS Number: 6600-40-4
Sum Formula: C₅H₁₁NO₂
Molar Mass: 117.15 g/mol
Appearance: White crystalline powder

L-Norvaline is a non-proteinogenic α-amino acid structurally related to valine but differing by the linear (unbranched) side chain. It is used in chemical research, material development, and as a building block in the synthesis of specialized amino acid derivatives and peptides.

Chemical and Physical Properties
Density: ~1.0–1.1 g/cm³ (estimated)
Melting Point: 295–298°C (with decomposition)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Freely soluble
Solubility in Other Solvents: Slightly soluble in ethanol; practically insoluble in ether and chloroform
Odor: Odorless

Applications
Organic Synthesis: Used as a precursor for non-natural peptides, peptidomimetics, and specialty ligands.
Biochemical Research: Studied for its role in nitrogen metabolism and as a structural analog of branched-chain amino acids.
Material Science: Investigated for incorporation into biodegradable polymers and functional materials.
Analytical Chemistry: Applied as a standard or intermediate in amino acid profiling and derivatization studies.
Coordination Chemistry: Explored as a ligand for metal complexation due to its amine and carboxylate functional groups.

Safety

Signal Word: Warning

Handling and Storage
Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated place. Protect from moisture, light, and oxidizing agents.
Handling Precautions: Avoid dust formation and inhalation. Use appropriate PPE and follow general chemical safety practices.