Aspartame

Aspartame
Other Names: L-Aspartyl-L-phenylalanine methyl ester
CAS Number: 22839-47-0
Sum Formula: C₁₄H₁₈N₂O₅
Molar Mass: 294.30 g/mol
Appearance: White crystalline powder

Aspartame is a synthetic dipeptide compound consisting of aspartic acid and phenylalanine methyl ester. While widely recognized for its high relative sweetness in consumer applications, in non-food contexts aspartame can serve as a model compound for peptide hydrolysis, a nitrogen-containing organic molecule in reaction systems, or a non-reactive additive in technical and laboratory settings.

Chemical and Physical Properties
Density: ~1.35 g/cm³
Melting Point: ~246–247°C (with decomposition)
Solubility in Water: Moderately soluble (~10 g/L at 25°C)
Solubility in Organic Solvents: Slightly soluble in ethanol; insoluble in non-polar solvents
Odor: Odorless
Stability: Stable under dry, neutral pH conditions; decomposes in heat and alkaline media

Applications
Used in laboratory studies related to peptide bond behavior and enzymatic hydrolysis
Applied as a model compound for controlled release or degradation testing
Can be used in industrial formulations where neutral, water-soluble dipeptides are required
Employed in research on amino acid derivatives and nitrogen-carrying organics

Safety

First Aid Measures
Eye Contact: Rinse with plenty of water for several minutes. Seek medical attention if irritation develops
Skin Contact: Wash with soap and water
Inhalation: Move to fresh air. Seek attention if discomfort occurs
Ingestion: Rinse mouth. Seek medical advice if symptoms appear

Handling and Storage
Store in a dry, cool, and well-ventilated place
Keep container tightly closed and protect from moisture and high temperatures
Avoid creating dust; use suitable PPE during handling