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N-Acetyl-L-glutamine Powder
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Description
N-Acetyl-L-glutamine
Other Names: Aceglutamide, N-Acetylglutamine, L-Glutamine, N²-acetyl-
CAS Number: 2490-97-3
Sum Formula: C₇H₁₂N₂O₄
Molar Mass: 188.18 g/mol
Appearance: White to off-white crystalline powder
N-Acetyl-L-glutamine is an N-acetylated derivative of the naturally occurring amino acid L-glutamine. The acetylation of the amine group enhances its chemical stability and modulates its reactivity, making it useful in synthetic and analytical chemistry as well as in technical applications involving amino acid derivatives.
Chemical and Physical Properties
Density: ~1.36 g/cm³ (estimated)
Melting Point: 189–192°C (with decomposition)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Soluble (~20 g/L at 25°C)
Solubility in Other Solvents: Slightly soluble in ethanol; insoluble in ether
Odor: Odorless
Applications
Organic Synthesis: Used as an intermediate in the synthesis of peptides and N-acyl amino acid derivatives.
Analytical Chemistry: Applied in chromatographic and spectroscopic studies of amino acid behavior and derivatization.
Technical Formulations: Incorporated into specialized biochemical buffers and stability-modified amino acid systems.
Peptide and Polymer Chemistry: Investigated in biodegradable materials and conjugation systems.
Safety
Signal Word: Warning
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Handling and Storage
Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated place. Protect from moisture and incompatible substances such as strong oxidizers.
Handling Precautions: Avoid creating dust. Use appropriate PPE and follow standard chemical handling procedures.