2,5-DIMETHOXY-BETA-NITROSTYRENE

2,5-Dimethoxy-β-nitrostyrene
Other Names:

• 1,4-Dimethoxy-2-(2-nitroethenyl)benzene

• 2,5-Dimethoxynitrostyrene

• 1,4-Dimethoxy-2-[(1E)-2-nitroethenyl]benzene

CAS Number: 40276-11-7
Sum Formula: C₁₀H₁₁NO₄
Molar Mass: 209.20 g/mol
Appearance: Yellow to orange crystalline solid or powder

2,5-Dimethoxy-β-nitrostyrene is a nitroalkene derivative featuring a styrene-like core with two methoxy substituents in the 2,5-positions on the aromatic ring. It is widely used in organic synthesis, particularly in the preparation of substituted phenethylamines and in research focused on nitroalkene reactivity.

Chemical and Physical Properties
Density: Approx. 1.30 g/cm³ (estimated)
Melting Point: ~95–98°C
Boiling Point: Decomposes before boiling
Solubility in Water: Practically insoluble
Solubility in Other Solvents: Soluble in ethanol, acetone, dichloromethane, and other polar organic solvents
Odor: Mild aromatic odor

Applications
Organic Synthesis: Intermediate in the synthesis of methoxy-substituted aromatic compounds and phenethylamine analogues.
Chemical Research: Used in the study of conjugated nitroalkenes, especially in Michael addition and cycloaddition reactions.
Materials Chemistry: Investigated in the preparation of fluorophores and functionalized molecular materials.

Safety
Signal Word: Warning

Hazard Statements:
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H411: Toxic to aquatic life with long lasting effects

Precautionary Statements – Prevention:
P261: Avoid breathing dust or vapors
P264: Wash hands thoroughly after handling
P273: Avoid release to the environment
P280: Wear protective gloves and eye protection

Precautionary Statements – Response:
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
P302+P352: IF ON SKIN: Wash with plenty of water
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
P337+P313: If eye irritation persists: Get medical advice/attention

Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated place. Protect from moisture, heat, and strong oxidizing agents.
Handling Precautions: Avoid dust formation and contact with skin or eyes. Use proper PPE and operate under good laboratory safety practices.