1-(2,4,5-TRIMETHOXYPHENYL)-2-NITROPROPENE

1-(2,4,5-Trimethoxyphenyl)-2-nitropropene
Other Names:

• Benzene, 1,2,4-trimethoxy-5-(2-nitro-1-propen-1-yl)-

• (E)-2-nitro-1-(2′,4′,5′-trimethoxyphenyl)prop-1-ene

• 1-(2,4,5-Trimethoxyphenyl)-2-nitropropene

CAS Number: 5556-76-3
Sum Formula: C₁₂H₁₅NO₅
Molar Mass: 253.25 g/mol
Appearance: Yellow to orange crystalline powder

1-(2,4,5-Trimethoxyphenyl)-2-nitropropene is a substituted aromatic nitroalkene. It features a phenyl ring substituted with three methoxy groups and a nitropropene side chain. It is used primarily in chemical research and synthesis, especially in studies involving aromatic nitro compounds and potential precursor transformations.

Chemical and Physical Properties
Density: Approx. 1.30 g/cm³ (estimated)
Melting Point: 90–94°C
Boiling Point: Decomposes before boiling
Solubility in Water: Practically insoluble
Solubility in Other Solvents: Soluble in organic solvents such as ethanol, methanol, acetone, DCM
Odor: Odorless or faint aromatic odor

Applications
Organic Synthesis: Used as an intermediate in research involving substituted aromatic compounds and nitroalkene derivatives.
Chemical Research: Studied for its structural properties and reactivity in nucleophilic and electrophilic additions.
Material Chemistry: Sometimes explored in the development of functionalized aromatic materials.

Safety
Signal Word: Warning

Hazard Statements:
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H411: Toxic to aquatic life with long lasting effects

Precautionary Statements – Prevention:
P261: Avoid breathing dust or vapors
P264: Wash hands thoroughly after handling
P273: Avoid release to the environment
P280: Wear protective gloves and eye protection

Precautionary Statements – Response:
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell
P302+P352: IF ON SKIN: Wash with plenty of water
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
P337+P313: If eye irritation persists: Get medical advice/attention

Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated place. Protect from light, heat, and incompatible substances such as strong oxidizers and acids.
Handling Precautions: Avoid generation of dust. Handle with appropriate protective equipment and under standard laboratory safety procedures.