Tetrahydrofurane ( THF ) Oxolane Analytically Pure - 500ml

Tetrahydrofuran (THF)
Other Names: Oxolane, 1,4-Epoxybutane, Butylene oxide
Chemical Formula: C₄H₈O
Molar Mass: 72.11 g/mol
CAS Number: 109-99-9
Purity: Analytically pure
Appearance: Clear, colorless, highly volatile liquid
Odor: Mild ether-like odor

Tetrahydrofuran is a low-viscosity, polar aprotic solvent widely used in chemical synthesis and industrial applications. It is a heterocyclic ether and one of the most versatile organic solvents, completely miscible with water and most organic liquids.

Chemical and Physical Properties

• Density: ~0.889 g/cm³ at 20 °C

• Boiling Point: 66 °C

• Melting Point: −108.5 °C

• Vapor Pressure: ~173 mmHg at 20 °C

• Solubility: Miscible with water, alcohols, ethers, and most organic solvents

• Flash Point: −14 °C (closed cup)

• Autoignition Temperature: 321 °C

• Explosive Limits: 1.5–12% (v/v in air)

• Stability: Can form explosive peroxides upon prolonged storage in air

Applications

Organic Synthesis

• Used as a reaction solvent for Grignard reactions, organolithium compounds, and polymerization processes.

Polymer Chemistry

• Solvent and processing agent in the synthesis of polyurethanes and elastomers (e.g. PTMEG production).

Analytical Chemistry

• Employed as a high-purity solvent in chromatographic and spectroscopic techniques.

Coatings and Adhesives

• Acts as a carrier solvent in specialized industrial coatings and bonding agents.

Safety

Signal Word: Danger

Hazard Statements:

• H225: Highly flammable liquid and vapor

• H302: Harmful if swallowed

• H319: Causes serious eye irritation

• H336: May cause drowsiness or dizziness

• H351: Suspected of causing cancer

• H372: Causes damage to organs through prolonged or repeated exposure

Precautionary Statements:

• P210: Keep away from heat/sparks/open flames/hot surfaces. No smoking

• P261: Avoid breathing vapors

• P280: Wear protective gloves/eye protection/face protection

• P303+P361+P353: IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse skin with water

• P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing

• P403+P235: Store in a well-ventilated place. Keep cool

• P501: Dispose of contents/container in accordance with local/regional/national regulations

Handling and Storage

• Storage: Keep container tightly closed in a cool, dry, well-ventilated area. Store under inert gas if long-term storage is required to prevent peroxide formation.

• Handling: Avoid inhalation and contact with skin or eyes. Ground and bond containers to prevent static discharge.

• Peroxide Formation: Monitor regularly. Add stabilizers or inhibitors if applicable.

Environmental Considerations

THF is moderately volatile and can contaminate air and water if released in large quantities. Proper containment and disposal are essential to prevent environmental harm.