D-Camphor-β-sulfonic Acid

D-Camphor-β-sulfonic Acid
Other Names: CSA, 10-Camphorsulfonic acid, Camphorsulfonic acid (D-form)
CAS Number: 5872-08-2
Sum Formula: C₁₀H₁₆O₄S
Molar Mass: 232.30 g/mol
Appearance: White crystalline solid, hygroscopic

D-Camphor-β-sulfonic acid is a chiral sulfonic acid derived from camphor. It is widely used as a Brønsted acid catalyst, resolving agent, and chiral auxiliary in organic synthesis. Thanks to its strong acidity and stereochemical properties, it is employed in asymmetric synthesis and enantioselective transformations.

Chemical and Physical Properties
Density: ~1.4 g/cm³
Melting Point: 193–195°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Readily soluble
Solubility in Organic Solvents: Soluble in alcohols and polar organic solvents
Stability: Hygroscopic; stable under recommended storage

Applications
Catalyst in organic synthesis (e.g., acetalization, esterification)
Resolving agent for chiral amines and other compounds
Used in asymmetric synthesis and stereochemical studies
Laboratory reagent for fine chemical and academic research

Safety

Signal Word: Warning

Hazard Statements

H314 Causes severe skin burns and eye damage.

Precautionary Statements

P260 Do not breathe dust.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.

P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P363 Wash contaminated clothing before reuse.

First Aid Measures
Eye Contact: Rinse with water for several minutes. Seek medical attention if irritation persists
Skin Contact: Wash with soap and water. Remove contaminated clothing
Inhalation: Move to fresh air. Seek medical advice if symptoms develop
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical help if unwell

Handling and Storage
Store in a tightly closed container in a cool, dry, and well-ventilated area
Protect from moisture (hygroscopic)
Keep away from strong bases and oxidizing agents