SLU-PP-332

(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide 

Pure compound

SLU-PP-332 is an experimental small-molecule research compound identified as a potent, non-selective agonist of estrogen-related receptors (ERRs), with its strongest activity reported at ERRα. In preclinical studies, it has been associated with increased mitochondrial activity, enhanced fatty-acid oxidation, higher energy expenditure, and improved exercise-related metabolic responses in mice. Current evidence is limited to laboratory and animal research, and SLU-PP-332 is not an approved medicine for human use.

Chemical and Physical Properties

• Chemical name: (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
• CAS number: 303760-60-3
• Molecular formula: C18H14N2O2
• Molecular weight / molar mass: 290.32 g/mol
• Monoisotopic mass / exact mass: 290.1055 Da
• Topological polar surface area (TPSA): 61.7 Ų
• XLogP: 3.7
• Hydrogen bond donors: 2
• Hydrogen bond acceptors: 3
• Rotatable bonds: 3
• Heavy atom count: 22
• Complexity: 402
• Appearance: white to off-white solid/powde

Synonyms: 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide, CHEMBL4208749, ERR pan-Agonist 332, SR9861

Applications

⚠️ Not intended for use in food, cosmetic, or pharmaceutical applications.

Handling and Storage

Handling: Avoid contact with skin, eyes, and clothing. Prevent inhalation of dust. Use only with adequate ventilation.
Storage: Store tightly sealed, in a cool, dry environment. Protect from moisture and incompatible reagents (especially bases and strong oxidizers).