Pyridoxal Phosphate
Other Names: Pyridoxal 5-phosphate, Pyridoxal 5'-phosphate, Codecarboxylase

CAS Number: 54-47-7
Sum Formula: C₈H₁₀NO₆P
Molar Mass: 247.14 g/mol
Appearance: Yellow to orange crystalline powder

Pyridoxal phosphate (PLP) is the active coenzyme form of vitamin B6. It contains a phosphorylated pyridine ring system and serves as an essential cofactor in many enzymatic reactions, particularly those involving amino acids. It is widely studied in biochemical research and synthetic organic chemistry involving catalytic transformations.

Chemical and Physical Properties
Density: ~1.5 g/cm³ (estimated)
Melting Point: 140–143°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Soluble (approximately 10 g/L at 25°C)
Solubility in Other Solvents: Slightly soluble in ethanol; practically insoluble in ether and chloroform
Odor: Odorless

Applications
Biochemical Research: Used to study enzyme catalysis, particularly transaminations, decarboxylations, and racemizations.
Organic Synthesis: Applied as a catalyst or cofactor mimic in asymmetric transformations.
Analytical Chemistry: Employed as a standard in vitamin B6 assays and enzyme activity measurements.
Material Science: Investigated in biomimetic systems and functionalized biochemical polymers.
Cofactor Development: Studied in the design of synthetic coenzyme systems and biochemical models.

Safety
Signal Word: Warning

Hazard Statements:
H319: Causes serious eye irritation
H335: May cause respiratory irritation

Precautionary Statements – Prevention:
P261: Avoid breathing dust
P264: Wash hands thoroughly after handling
P271: Use only in a well-ventilated area
P280: Wear protective gloves and eye protection

Precautionary Statements – Response:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing
P337+P313: If eye irritation persists: Get medical advice/attention
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing

Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, and dark place. Protect from moisture, light, and strong oxidizing agents.
Handling Precautions: Avoid dust formation and exposure to air. Use PPE and maintain standard laboratory safety measures.