S-Adenosyl methionine (SAMe)
Other Names: S-Adenosyl-L-methionine, SAM-e, SAMe, Adomet, Ademethionine

CAS Number: 29908-03-0
Sum Formula: C₁₅H₂₂N₆O₅S
Molar Mass: 398.44 g/mol
Appearance: White to off-white crystalline powder

S-Adenosyl methionine (SAMe) is a sulfonium compound formed by the reaction of ATP and methionine. It serves as a principal biological methyl donor and participates in numerous biochemical reactions, making it a critical molecule in chemical research involving methylation, aminopropylation, and sulfur transfer.

Chemical and Physical Properties
Density: ~1.5 g/cm³ (estimated)
Melting Point: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Solubility in Water: Freely soluble
Solubility in Other Solvents: Slightly soluble in alcohol; practically insoluble in nonpolar solvents
Odor: Odorless

Applications
Organic Chemistry: Used in the synthesis of methylated compounds through methyl group transfer reactions.
Biochemical Research: Studied extensively for its role as a methyl donor in DNA, RNA, protein, and lipid methylation.
Enzymology: Investigated as a cofactor for methyltransferase enzymes.
Material Science: Explored for use in biomaterials incorporating sulfonium structures for controlled reactivity.
Analytical Chemistry: Applied in methylation assays and studies of transmethylation processes.

Safety

Signal Word: Warning

Handling and Storage
Storage Conditions: Store in a tightly sealed container at low temperatures (preferably refrigerated) in a dry and dark environment. Protect from moisture, light, and oxidation.
Handling Precautions: Handle under inert atmosphere when possible for long-term stability. Use appropriate PPE and maintain standard laboratory safety procedures.