L-Isoleucine
Other Names: Isoleucine, (2S,3S)-2-Amino-3-methylpentanoic acid

CAS Number: 73-32-5
Sum Formula: C₆H₁₃NO₂
Molar Mass: 131.18 g/mol
Appearance: White crystalline powder

L-Isoleucine is one of the essential α-amino acids, containing a branched aliphatic side chain. It is a proteinogenic amino acid with a critical role in protein structure and function. L-Isoleucine is also studied in materials science and organic synthesis involving peptide and polymer chemistry.

Chemical and Physical Properties
Density: ~1.29 g/cm³
Melting Point: 284–286°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Freely soluble (~41 g/L at 20°C)
Solubility in Other Solvents: Slightly soluble in alcohol; practically insoluble in ether and chloroform
Odor: Odorless

Applications
Peptide Synthesis: Used as a building block in the preparation of peptides and proteins.
Organic Synthesis: Applied as an intermediate in the synthesis of amino acid derivatives and biopolymers.
Analytical Chemistry: Utilized as a reference standard in amino acid analysis and chromatography.
Material Science: Investigated for incorporation into bio-based polymers and hydrogels.
Biochemical Research: Studied in metabolic and enzymatic systems related to branched-chain amino acids.

Safety

This chemical does not meet GHS hazard criteria for 98.8% (169 of 171) of all reports.

Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated environment. Protect from moisture and strong oxidizing agents.
Handling Precautions: Avoid dust generation and contact with eyes or skin. Use appropriate PPE and follow standard laboratory safety practices.