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Producenci
Histydyna w proszku (alkaliczna)
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Opis
Histidine
Other Names: L-Histidine, H-His-OH, Glyoxaline-5-alanine, (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid
CAS Number: 71-00-1
Sum Formula: C₆H₉N₃O₂
Molar Mass: 155.15 g/mol
Appearance: White to off-white crystalline powder
L-Histidine is a naturally occurring α-amino acid characterized by the presence of an imidazole functional group. It is one of the proteinogenic amino acids and plays a significant role in coordination chemistry, buffering systems, and as a ligand in metal-binding studies.
Chemical and Physical Properties
Density: ~1.43 g/cm³ (estimated)
Melting Point: ~287°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Soluble (~41 g/L at 25°C)
Solubility in Other Solvents: Slightly soluble in ethanol; insoluble in ether
Odor: Odorless
Applications
Buffer Systems: Used in the formulation of biological and biochemical buffers due to its imidazole side chain's pKa.
Coordination Chemistry: Acts as a bidentate ligand in metal complexation studies.
Peptide Synthesis: Building block in the synthesis of histidine-containing peptides and conjugates.
Analytical Chemistry: Studied for its chelating properties and UV-absorption characteristics.
Material Science: Investigated in biomimetic and functionalized polymer systems.
Safety
Signal Word: Warning
H302 (25.3%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (25.9%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (25.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (25.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, and P501
Handling and Storage
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated area. Protect from light and moisture.
Handling Precautions: Avoid dust formation and contact with eyes or mucous membranes. Use appropriate PPE and standard laboratory practices.